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Denosumab in Treating Patients With Recurrent or Refractory Osteosarcoma
Overview
Status | Active not recruiting |
---|---|
Phase | Phase 2 |
Sponsor | Children's Oncology Group |
Start date | November 2015 |
End date | December 2019 |
Enrollment | 56 participants |
Identifiers | NCT02470091, AOST1321, NCI-2015-00543, s15-01360, AOST1321, AOST1321, AOST1321, U10CA180886 |
Conditions
Metastatic Osteosarcoma, Recurrent Osteosarcoma, Refractory Osteosarcoma, Stage IV Osteosarcoma AJCC v7, Stage IVA Osteosarcoma AJCC v7, Stage IVB Osteosarcoma AJCC v7
Treatments
Denosumab, Laboratory Biomarker Analysis, Pharmacological Study
Summary
This phase II trial studies how well denosumab works in treating patients with osteosarcoma that has come back (recurrent) or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as denosumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Locations
Children's Hospital of Alabama | |
Birmingham, Alabama | |
Phoenix Childrens Hospital | |
Phoenix, Arizona | |
Banner University Medical Center - Tucson | |
Tucson, Arizona | |
Arkansas Children's Hospital | |
Little Rock, Arkansas | |
Kaiser Permanente-Anaheim | |
Anaheim, California | |
Kaiser Permanente-Bellflower | |
Bellflower, California | |
Kaiser Permanente Downey Medical Center | |
Downey, California | |
Kaiser Permanente-Fontana | |
Fontana, California | |
Loma Linda University Medical Center | |
Loma Linda, California | |
Children's Hospital Los Angeles | |
Los Angeles, California | |
Kaiser Permanente Los Angeles Medical Center | |
Los Angeles, California | |
Valley Children's Hospital | |
Madera, California | |
Children's Hospital and Research Center at Oakland | |
Oakland, California | |
Children's Hospital of Orange County | |
Orange, California | |
University of California Davis Comprehensive Cancer Center | |
Sacramento, California | |
Kaiser Permanente-San Diego Zion | |
San Diego, California | |
Rady Children's Hospital - San Diego | |
San Diego, California | |
UCSF Medical Center-Mission Bay | |
San Francisco, California | |
Children's Hospital Colorado | |
Aurora, Colorado | |
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | |
Denver, Colorado | |
Connecticut Children's Medical Center | |
Hartford, Connecticut | |
Alfred I duPont Hospital for Children | |
Wilmington, Delaware | |
Children's National Medical Center | |
Washington, District of Columbia | |
University of Florida Health Science Center - Gainesville | |
Gainesville, Florida | |
Nemours Children's Clinic-Jacksonville | |
Jacksonville, Florida | |
Nicklaus Children's Hospital | |
Miami, Florida | |
University of Miami Miller School of Medicine-Sylvester Cancer Center | |
Miami, Florida | |
AdventHealth Orlando | |
Orlando, Florida | |
Nemours Children's Hospital | |
Orlando, Florida | |
Johns Hopkins All Children's Hospital | |
Saint Petersburg, Florida | |
Saint Joseph's Hospital/Children's Hospital-Tampa | |
Tampa, Florida | |
Saint Mary's Hospital | |
West Palm Beach, Florida | |
Children's Healthcare of Atlanta - Egleston | |
Atlanta, Georgia | |
Kapiolani Medical Center for Women and Children | |
Honolulu, Hawaii | |
Saint Luke's Mountain States Tumor Institute | |
Boise, Idaho | |
Centralia Oncology Clinic | |
Centralia, Illinois | |
Lurie Children's Hospital-Chicago | |
Chicago, Illinois | |
University of Chicago Comprehensive Cancer Center | |
Chicago, Illinois | |
University of Illinois | |
Chicago, Illinois | |
Carle on Vermilion | |
Danville, Illinois | |
Cancer Care Specialists of Illinois - Decatur | |
Decatur, Illinois | |
Carle Physician Group-Effingham | |
Effingham, Illinois | |
Crossroads Cancer Center | |
Effingham, Illinois | |
Carle Physician Group-Mattoon/Charleston | |
Mattoon, Illinois | |
Cancer Care Center of O'Fallon | |
O'Fallon, Illinois | |
Saint Jude Midwest Affiliate | |
Peoria, Illinois | |
Carle Cancer Center | |
Urbana, Illinois | |
The Carle Foundation Hospital | |
Urbana, Illinois | |
Riley Hospital for Children | |
Indianapolis, Indiana | |
Saint Vincent Hospital and Health Care Center | |
Indianapolis, Indiana | |
University of Iowa/Holden Comprehensive Cancer Center | |
Iowa City, Iowa | |
University of Kentucky/Markey Cancer Center | |
Lexington, Kentucky | |
Norton Children's Hospital | |
Louisville, Kentucky | |
Ochsner Medical Center Jefferson | |
New Orleans, Louisiana | |
Maine Children's Cancer Program | |
Scarborough, Maine | |
Johns Hopkins University/Sidney Kimmel Cancer Center | |
Baltimore, Maryland | |
Sinai Hospital of Baltimore | |
Baltimore, Maryland | |
Walter Reed National Military Medical Center | |
Bethesda, Maryland | |
Brigham and Women's Hospital | |
Boston, Massachusetts | |
Dana-Farber Cancer Institute | |
Boston, Massachusetts | |
UMass Memorial Medical Center - University Campus | |
Worcester, Massachusetts | |
C S Mott Children's Hospital | |
Ann Arbor, Michigan | |
Ascension Saint John Hospital | |
Detroit, Michigan | |
Wayne State University/Karmanos Cancer Institute | |
Detroit, Michigan | |
Helen DeVos Children's Hospital at Spectrum Health | |
Grand Rapids, Michigan | |
Bronson Methodist Hospital | |
Kalamazoo, Michigan | |
Children's Hospitals and Clinics of Minnesota - Minneapolis | |
Minneapolis, Minnesota | |
University of Minnesota/Masonic Cancer Center | |
Minneapolis, Minnesota | |
Mayo Clinic in Rochester | |
Rochester, Minnesota | |
University of Mississippi Medical Center | |
Jackson, Mississippi | |
Children's Mercy Hospitals and Clinics | |
Kansas City, Missouri | |
Mercy Hospital Saint Louis | |
Saint Louis, Missouri | |
Washington University School of Medicine | |
Saint Louis, Missouri | |
Children's Hospital and Medical Center of Omaha | |
Omaha, Nebraska | |
University of Nebraska Medical Center | |
Omaha, Nebraska | |
Alliance for Childhood Diseases/Cure 4 the Kids Foundation | |
Las Vegas, Nevada | |
Sunrise Hospital and Medical Center | |
Las Vegas, Nevada | |
Dartmouth Hitchcock Medical Center | |
Lebanon, New Hampshire | |
Hackensack University Medical Center | |
Hackensack, New Jersey | |
Rutgers Cancer Institute of New Jersey | |
New Brunswick, New Jersey | |
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | |
New Brunswick, New Jersey | |
Newark Beth Israel Medical Center | |
Newark, New Jersey | |
University of New Mexico Cancer Center | |
Albuquerque, New Mexico | |
Albany Medical Center | |
Albany, New York | |
Roswell Park Cancer Institute | |
Buffalo, New York | |
Laura and Isaac Perlmutter Cancer Center at NYU Langone | |
New York, New York | |
Memorial Sloan Kettering Cancer Center | |
New York, New York | |
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | |
New York, New York | |
University of Rochester | |
Rochester, New York | |
State University of New York Upstate Medical University | |
Syracuse, New York | |
UNC Lineberger Comprehensive Cancer Center | |
Chapel Hill, North Carolina | |
Carolinas Medical Center/Levine Cancer Institute | |
Charlotte, North Carolina | |
Wake Forest University Health Sciences | |
Winston-Salem, North Carolina | |
Sanford Broadway Medical Center | |
Fargo, North Dakota | |
Children's Hospital Medical Center of Akron | |
Akron, Ohio | |
UHHS-Chagrin Highlands Medical Center | |
Beachwood, Ohio | |
Cincinnati Children's Hospital Medical Center | |
Cincinnati, Ohio | |
Case Western Reserve University | |
Cleveland, Ohio | |
Cleveland Clinic Foundation | |
Cleveland, Ohio | |
Rainbow Babies and Childrens Hospital | |
Cleveland, Ohio | |
Nationwide Children's Hospital | |
Columbus, Ohio | |
Dayton Children's Hospital | |
Dayton, Ohio | |
University of Oklahoma Health Sciences Center | |
Oklahoma City, Oklahoma | |
Oregon Health and Science University | |
Portland, Oregon | |
Penn State Children's Hospital | |
Hershey, Pennsylvania | |
Children's Hospital of Philadelphia | |
Philadelphia, Pennsylvania | |
Children's Oncology Group | |
Philadelphia, Pennsylvania | |
Saint Christopher's Hospital for Children | |
Philadelphia, Pennsylvania | |
Children's Hospital of Pittsburgh of UPMC | |
Pittsburgh, Pennsylvania | |
Rhode Island Hospital | |
Providence, Rhode Island | |
Medical University of South Carolina | |
Charleston, South Carolina | |
Prisma Health Richland Hospital | |
Columbia, South Carolina | |
Sanford USD Medical Center - Sioux Falls | |
Sioux Falls, South Dakota | |
Saint Jude Children's Research Hospital | |
Memphis, Tennessee | |
Vanderbilt University/Ingram Cancer Center | |
Nashville, Tennessee | |
Dell Children's Medical Center of Central Texas | |
Austin, Texas | |
Driscoll Children's Hospital | |
Corpus Christi, Texas | |
Medical City Dallas Hospital | |
Dallas, Texas | |
UT Southwestern/Simmons Cancer Center-Dallas | |
Dallas, Texas | |
Cook Children's Medical Center | |
Fort Worth, Texas | |
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | |
Houston, Texas | |
Children's Hospital of San Antonio | |
San Antonio, Texas | |
University of Texas Health Science Center at San Antonio | |
San Antonio, Texas | |
Primary Children's Hospital | |
Salt Lake City, Utah | |
University of Vermont and State Agricultural College | |
Burlington, Vermont | |
University of Virginia Cancer Center | |
Charlottesville, Virginia | |
Children's Hospital of The King's Daughters | |
Norfolk, Virginia | |
Virginia Commonwealth University/Massey Cancer Center | |
Richmond, Virginia | |
Seattle Children's Hospital | |
Seattle, Washington | |
Providence Sacred Heart Medical Center and Children's Hospital | |
Spokane, Washington | |
West Virginia University Healthcare | |
Morgantown, West Virginia | |
Children's Hospital of Wisconsin | |
Milwaukee, Wisconsin | |
Centre Hospitalier Universitaire de Quebec | |
Quebec, Canada | |
University of Alberta Hospital | |
Edmonton, Canada | |
IWK Health Centre | |
Halifax, Canada | |
McMaster Children's Hospital at Hamilton Health Sciences | |
Hamilton, Canada | |
Children's Hospital | |
London, Canada | |
Hospital for Sick Children | |
Toronto, Canada | |
The Montreal Children's Hospital of the MUHC | |
Montreal, Canada | |
San Jorge Children's Hospital | |
San Juan, Puerto Rico | |
University Pediatric Hospital | |
San Juan, Puerto Rico |